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60 tablets*5 boxes. Zhenju Jiangya Pian for the treatment of hypertension.

60 tablets*5 boxes. Zhenju Jiangya Pian for the treatment of hypertension.

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Zhenju Jiangya Pian
Zhen Ju Jiang Yan Pian
Zhenjujiangya Pian
Zhenju Jiangya Tablets
Zhen Ju Jiang Yan Tablets

FUNCTION and INDICATIONS
Used for hypertension.

INGREDIENTS
Wild Chrysanthemum Cream Powder,Nacre powder,Clonidine hydrochloride, Hydrochlorothiazide, Rutin.

DESCPRIPTION
This product is film-coated tablet, which is yellow-brown after removing the coating; bitter taste.

SPECIFICATION AND PACKAGE
0.25g*60 tablets/box.

USAGE AND DOSAGE
For oral use after meals,1 tablet 3 times daily or by medical ordor.

REFERENCES

ADVERSE REACTION
1.Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea or constipation, jaundice, abnormal liver function, drug-induced hepatitis, cholecystitis, etc.
2.Mental and nervous system: dizziness, headache, insomnia, drowsiness, depression, mental tension, anxiety, restlessness, temporary mental disorder and other behavior changes, dreams or nightmares, visual and auditory hallucinations, etc.
3.Skin and its accessories: skin rash, dermatitis, itching, hyperhidrosis, angioedema, hair loss, etc. Exfoliative dermatitis may occur in severe cases.
4.Systemic: dry mouth, fatigue, allergic reactions, edema, fever, pain, clonidine withdrawal reaction, weight gain, alcohol allergy, etc.
5.Metabolism and nutrition: hypokalemia, hyponatremia, hyperuricemia, elevated blood sugar, elevated serum creatine phosphokinase concentration, hypochlorine alkalosis or hypochlorine hypokalemia alkalosis, etc.
6.Urinary system: frequent urination, urgency, dysuria, urinary retention, nocturia, hematuria, abnormal renal function, etc.
7.Respiratory system: coughing, holding breath, dyspnea, etc.
8.Cardiovascular system: orthostatic hypotension, hypotension, syncope, chest tightness, palpitations, tachycardia, bradycardia, abnormal electrocardiogram (eg: sinus node block, borderline bradycardia, atrioventricular block Stagnation, etc.), heart failure, etc.
9.Blood system: purpura, bleeding gums, leukopenia, thrombocytopenia, Coombs test is weakly positive.
10.Reproductive system: decreased male sexual function, male breast development.
11.Musculoskeletal system: muscle or joint pain, spasm of lower limbs.
12.Vision: dry eyes, burning eyes, blurred vision and color vision disorders.
13.Others: pancreatitis, mumps, light sensitivity, etc.

CONTRAINDICATIONS
1.People who are allergic to this product should not use it.
2.Those who are allergic to the ingredients in the prescription or sulfa drugs are prohibited.
3.Contraindicated in pregnant and lactating women.
Children's Medication
The safety and effectiveness of this product for children are unclear. It should be used with caution in infants with jaundice, because the component of this product, hydrochlorothiazide, can increase blood bilirubin.
Medication for elderly patients
The elderly taking this product are more prone to hypotension, electrolyte imbalance and renal damage.

Warning
1.This product should not be used as the first choice for the treatment of hypertension.
2.Pay attention to the dosage: each tablet of this product contains Clonidine Hydrochloride 0.03mg, Hydrochlorothiazide 5mg, Rutin 20mg. When combined with drugs containing the above ingredients, the dosage of the same components in each drug should be calculated separately to avoid overdose.
3.Prevent withdrawal reaction: When stopping this product, the dosage should be reduced slowly within 2-4 days to avoid withdrawal reaction of the component of this product, clonidine hydrochloride. Discontinuation of the drug after combined use with β-blockers can increase the withdrawal response of clonidine hydrochloride. If it has been combined with β-blockers, β-blockers should be stopped first, and then hydrochloric acid should be stopped. Clonidine. Sequential administration with β-blockers should be avoided because it may cause or aggravate the withdrawal reaction of clonidine hydrochloride.
4.Monitoring blood pressure: The treatment of hypertension should be individualized as far as possible, and the changes in blood pressure should be monitored when the dosage is adjusted or other antihypertensive drugs are combined.
5.Avoid cross-allergic reactions: The components of this product have cross-allergic reactions with sulfa drugs, furosemide, bumetanide, carbonic anhydrase inhibitors, etc.
6.This product may cause hypokalemia, hyponatremia, hypercalcemia, hypochlorine alkalosis, hypochlorine hypokalemia alkalosis, and cause impaired glucose tolerance, increased blood sugar, and hyperuricemia. Use This product may aggravate or worsen existing water, electrolyte and metabolic disorders.
7.Patients with abnormal liver and kidney function should be used with caution. If necessary, liver and kidney function and water and electrolyte balance should be closely monitored.
8.Use with caution in patients with cerebrovascular disease, coronary artery insufficiency, recent myocardial infarction, Raynaud's disease, sinus node or atrioventricular conduction dysfunction, and thromboangiitis obliterans.
9.Use with caution for patients with pancreatitis and lupus erythematosus. This product can aggravate the condition or induce activity; this product may cause idiopathic acute myopia and secondary angle-closure glaucoma. If any of the above abnormalities occurs, the drug should be discontinued as soon as possible for symptomatic treatment.
10.Use with caution for people with achlorhydria and athletes.
11.This product can interfere with the parathyroid function test, which can make the Coombs test weakly positive and reduce the excretion of urinary catecholamines and vanillin mandelic acid (VMA).
12.During the period of taking the medicine, you should avoid driving or machine operation as much as possible.
13. Avoid smoking, alcohol and spicy and greasy food during the medication.
14 Medication for pregnant women and breastfeeding women: it is forbidden for pregnant women and breastfeeding women.
15.Children's medication: The safety and effectiveness of this product for children are still unclear. Use it with caution in infants with jaundice, because the component of this product, hydrochlorothiazide, can increase blood bilirubin.
16.Elderly medication: The elderly are more prone to hypotension, electrolyte imbalance and renal damage when taking this product.

DRUG INTERACTION
This product contains three chemical ingredients of clonidine hydrochloride, hydrochlorothiazide and rutin, and two traditional Chinese medicine ingredients of wild chrysanthemum ointment powder and nacre powder. When combining drugs, attention should be paid to the possible drug interactions between the drug and each component of this product. .
1.Interaction with hydrochlorothiazide (1) Adrenal cortex hormones, adrenocorticotropic hormone, estrogen, and amphotericin B (intravenous medication) can reduce the diuretic effect of hydrochlorothiazide, leading to electrolyte disorders, especially hypokalemia. . (2) Non-steroidal anti-inflammatory and analgesics, especially indomethacin, can reduce the diuretic effect of hydrochlorothiazide, which is related to the former's inhibition of prostaglandin synthesis. (3) Combined with sympathomimetic amine drugs, the diuretic effect is weakened. (4) Cholestyramine (cholestyramine) can reduce the absorption of hydrochlorothiazide from the gastrointestinal tract, so this medicine should be taken 1 hour before or 4 hours after oral cholestyramine. (5) When combined with dopamine, the diuretic effect is strengthened. (6) When combined with other antihypertensive drugs, the antihypertensive effect is strengthened. (7) When combined with gout drugs, the latter should be dosed. (8) The weakening of the anticoagulant effect is mainly due to the decrease in the body's plasma volume after diuresis and the increase in blood coagulation factor levels. In addition, diuresis improves the liver blood supply and increases the synthesis of coagulation factors. (9) Reduce the effect of hypoglycemic drugs. (10) When combined with digitalis, amiodarone, etc., pay attention to the side effects caused by hypokalemia. (11) Combined use with lithium preparations can increase the nephrotoxicity of lithium, because hydrochlorothiazide can reduce the elimination of lithium by the kidneys. (12) Enhancing the effect of non-depolarizing muscle relaxants is related to the decrease of serum potassium. (13) When combined with sodium bicarbonate, the chance of low-chlorine alkalosis is increased.
2 Interaction with clonidine hydrochloride (1) Combining with central nervous system depressants such as ethanol, barbiturates or sedatives can strengthen the central depressive effect. (2) Combination with other antihypertensive drugs can enhance the antihypertensive effect. (3) If the drug is stopped after combined use with a blocker, it can increase the withdrawal response of clonidine, so it is advisable to stop the blocker first, and then stop the clonidine. (4) Combine with tricyclic antidepressants to weaken the antihypertensive effect of clonidine. Clonidine must be increased. (5) Combined use with non-steroidal anti-inflammatory drugs to weaken the antihypertensive effect of clonidine. 3. The interaction with wild chrysanthemum is not suitable to take warm tonic Chinese medicine during the medication.

STORAGE
Hermetically sealed,keep in cool and dry places.

PERIOD OF VALIDITY
24 months.

CERTIFICATE NO
Stage Food and Drug Administration Approval number:Z20053333.

Manufactured
LEIYUNSHANG PHARMACEUTICAL CO.,LTD

Tips: Please read the directions for use in retail or directed by physician.
Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive.

General Cautions
Keep away from animals and children.This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health.
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