Category: Leigongteng

Wang Jie
Chief Physician
Department of Traditional Chinese Medicine, Shandong Provincial Hospital (Top-Tier Hospital)

Tripterygium Glycosides Tablets can be used to treat certain kidney diseases, primarily immune-related conditions such as chronic nephritis and nephrotic syndrome. Their mechanisms of action include anti-inflammatory and immunosuppressive effects.

1. Immunosuppressive Effect
Tripterygium Glycosides Tablets inhibit the proliferation of T lymphocytes and the release of inflammatory factors, thereby reducing immune-mediated damage to the kidneys. They are suitable for kidney diseases caused by immune abnormalities.

2. Anti-inflammatory Effect
The medication can reduce proteinuria and alleviate inflammatory reactions in the glomeruli. It shows certain efficacy in treating conditions such as membranous nephropathy and IgA nephropathy.

3. Combination Therapy
Tripterygium Glycosides Tablets are often used in combination with glucocorticoids to enhance therapeutic effects and reduce steroid dosage. However, liver function and blood tests must be monitored to avoid adverse reactions.

4. Usage Restrictions
The medication is contraindicated in patients with severe liver or kidney dysfunction. Patients of childbearing age must strictly practice contraception during treatment. Long-term use may cause menstrual disorders or reduced sperm count.

Important Notes:

• The use of Tripterygium Glycosides Tablets must strictly follow medical advice.
• Regular monitoring of urine tests and kidney function is required.
• Concomitant use with hepatotoxic drugs should be avoided.
• Symptoms such as fatigue or jaundice should prompt immediate medical attention.

Zeng Xiaofeng
Chief Physician, Department of Rheumatology and Immunology
Peking Union Medical College Hospital (Top-Tier Hospital)

Tripterygium is a traditional Chinese herb. An initially extracted component from it was previously known as Tripterygium Glycosides (雷公藤多甙) and is now referred to as Tripterygium Glycosides (雷公藤多苷). As research has progressed, it has been confirmed that Tripterygium exhibits certain therapeutic effects for conditions such as rheumatoid arthritis and systemic lupus erythematosus. It can achieve anti-inflammatory and analgesic effects while also controlling disease progression.

Of course, this medication also has its issues—its side effects still exist, particularly its impact on the gonads. For instance, its use in women of childbearing age can lead to menstrual disorders or even amenorrhea. Therefore, caution is essential when prescribing it to younger patients. Typically, the duration of use should not exceed three months. For rheumatoid arthritis patients, it is mostly prescribed to postmenopausal women.

It can be used in patients with rheumatoid arthritis or lupus nephritis and may also help reduce proteinuria. However, its impact on the gonads remains a concern that requires attention. During treatment, it is necessary to balance the relationship between side effects and efficacy to ultimately make the most appropriate therapeutic choice.

Zhu Mingwei
Chief Physician
Department of Nutrition, Beijing Hospital (Top-Tier Hospital)

Tripterygium Glycosides Tablets have anti-inflammatory and immunomodulatory effects and are primarily used to treat autoimmune diseases such as rheumatoid arthritis and nephrotic syndrome.

1. Anti-inflammatory Effect
   The active components in Tripterygium Glycosides Tablets can inhibit the synthesis of inflammatory mediators such as prostaglandins and leukotrienes, thereby reducing joint swelling and pain. They provide significant relief for inflammatory reactions caused by conditions like rheumatoid arthritis and ankylosing spondylitis.
2. Immunomodulatory Effect
   This medication can inhibit T lymphocyte proliferation and antibody production while reducing immunoglobulin levels. It is suitable for autoimmune diseases such as systemic lupus erythematosus and psoriasis. Its immunosuppressive effects help mitigate pathological immune attacks.
3. Improvement of Proteinuria
   By regulating the permeability of the glomerular basement membrane, Tripterygium Glycosides Tablets can reduce urinary protein excretion in patients with nephrotic syndrome. They are often used in combination with hormones to treat primary glomerular diseases.
4. Anti-fibrotic Effect
   This medication has a certain therapeutic effect on diseases such as pulmonary fibrosis and hepatic fibrosis. Its mechanism may involve inhibiting fibroblast activation and collagen deposition.
5. Application in Skin Diseases
   Tripterygium Glycosides Tablets are used to treat chronic skin conditions such as psoriasis and eczema, helping to alleviate symptoms like erythema, scaling, and itching. However, it is important to note that this medication may cause adverse reactions such as dry skin.

Important Considerations During Use:

• Regular monitoring of blood counts and liver/kidney function is required while taking Tripterygium Glycosides Tablets.
• Concomitant use with other immunosuppressants should be avoided.
• The medication is contraindicated for individuals planning pregnancy and pregnant women.
• If symptoms such as nausea or menstrual irregularities occur during treatment, seek medical attention promptly.
• Maintain a low-salt diet in daily life, focus on infection prevention, and engage in appropriate joint function exercises.